犬心脏, 肺动脉 CT 造影技术研究.

[Objectives]The aim of this study was to determine the optimal angiography protocol for canine heart and pulmonary artery angiography. [Methods]The variable iohexol concentrations were tested in this study to evaluate the effects on ardiac and pulmonary angiography, while injection duration and injection rate were same for the same size dogs. Iohexol dose(I content)from 100 to 200 mg·mL-1 were used in small dogs for ardiac angiography, 200 to 300 mg·mL-1 in middle dogs and 150 to 200 mg·mL-1 in large dogs. For pulmonary angiography, iohexol concentrations were 50 to 100 mg·mL-1 in small dogs, 50 to 100 mg·mL-1 in middle dogs and 150 to 200 mg·mL-1 in large dogs. Contrast agent was injected intravenously from cephalic veins after anesthesia. Dynamic scanning project was performed to obtain time-density curve of region of interest. Scanning delay time was calculated based on the time-density curve. The time to reach 200 HU aortic sinus was designated as delay time of cardiac angiography. The time to reach the peak enhancement of pulmonary artery trunk was designated as delay time of pulmonary arteriography. Then the images were obtained by volume scanning project. The images quality obtained by different contrast schemes were evaluated quantitatively and qualitatively to determine the optimal contrast scheme. [Results]The optimum cardiac angiography conditions for small dogs were 200 mg·mL-1 of iohexol concentration, 10 mL of iohexol volume, 5 mL of saline dose and 1 mL·s-1 of injection rate. For middle dogs, the optimum conditions were 250 mg·mL-1 of iohexol concentration, 15 mL of iohexol volume, 10 mL of saline dose and 1 mL·s-1 of injection rate. For large dogs, the optimum conditions were 350 mg·mL-1 of iohexol concentration, 30 mL of iohexol volume, 20 mL of saline dose and 1 mL·s-1 of injection rate. The optimum pulmonary arteriography conditions were as follows:75 mg·mL-1 of iohexol concentration, 15 mL of iohexol volume, 15 mL of saline dose and 5 mL·s-1 of injection rate in small dogs. For middle dogs those were 100 mg·mL-1 of iohexol concentration, 20 mL of iohexol volume, 20 mL of saline dose and 5 mL·s-1 of injection rate. And for large dogs those were 175 mg·mL-1 of iohexol concentration, 30 mL of iohexol volume, 30 mL of saline dose and 5 mL·s-1 of injection rate. The higher post-vascular enhancement CT values with good image quality and good contrast effects were obtained when used above conditions. [Conclusions]Through repeated tests, the contrast agent conditions used in this test can obtain satisfactory and clinically diagnostic images and can be applied to CT imaging of cardiac and pulmonary artery diseases in dogs. [ABSTRACT FROM AUTHOR]