奥氮平联合舍曲林对于奥氮平血药浓度的影响研究.

OBJECTIVE: To investigate whether olanzapine combined with sertraline can affect the blood concentration of olanzapine in vivo. METHODS: Drug monitoring results of olanzapine in a hospital from 2020 to 2021 were retrospectively reviewed. According to whether sertraline was used or not, all patients were divided into the combined group(68 cases) and control group(117 cases), and the blood concentration of olanzapine was compared between two groups. RESULTS: The blood concentrations of olanzapine in the combined group and control group were respectively (31. 68 ± 18. 58) ng/mL and (49. 86 ± 25. 63) ng/mL, the dose-adjusted blood concentrations were respectively (2. 08 ± 0. 88) ng·d/(mL·mg) and (2. 69 ± 1. 21) ng·d/( mL·mg), the combined group was significantly lower than the control group, with statistically significant differences ( P<0. 05 ). The ratio of concentrations below the lower limit of the therapeutic range in the combined group and control group were respectively 32. 35% (22/68) and 7. 69% (9/117), the combined group was significantly higher than the control group, and the difference was statistically significant (P<0. 05). CONCLUSIONS: Olanzapine combined with sertraline can decrease the blood concentration of olanzapine. When the two drugs are combined, it is recommended to monitor the changes in the blood concentration of olanzapine, and it may be necessary to increase the dose appropriately according to the clinical situation. [ABSTRACT FROM AUTHOR]