TRIM11 protects against tauopathies and is down-regulated in Alzheimer’s disease.

TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease INTRODUCTION: Tauopathies encompass Alzheimer's disease (AD), the most common form of dementia, as well as more than 20 other neurodegenerative disorders. To examine the role of TRIM11 in the mammalian brain and to evaluate its therapeutic potential, we used multiple mouse models of tauopathy, including PS19 mice, which express the familiar tau mutant P301L; PS19 mice injected with preformed tau fibrils to accentuate disease phenotypes; and 3×Tg-AD mice, which express tau P301L and familial mutations in two AD-related proteins, the amyloid precursor protein and presenilin 1. [Extracted from the article]