Correlation between cytological and histopathological grading of invasive ductal carcinoma breast and nodal metastasis.

Background: fine needle aspiration cytology FNAC plays a vital role in the initial evaluation and early diagnosis of the breast tumours, by providing the useful information on aggressiveness of the tumour as well as its prognosis. Aim: This study has been carried out to evaluate the correlation between the cytological & histopathological grading of invasive ductal carcinoma with specific reference to nodal metastasis & its role in prognostication. Material and methods: This was a cross sectional study in which Fifty six patients aged between 28-75 years who were cytologically proven duct cell carcinoma of breast with their corresponding histopathology. They were graded cytologically by Robinson's and correlated histologically with SBR grading method. Statical analysis was done using SPSS and Epi info online. Kohens kappa was calculated to assess the extent of agreement between two measurements. Diagnostic accuracy was calculated through sensitivity, specificity, positive predictive values and negative predictive values. Result: Using aspirate samples, cases were cytologically graded according to Robinsons categories according to Robinson categories, with the following results: Grade 1:11cases, Grade II: 37 Grade III: 8. Using histologic samples 14 cases were considered grade I, Cases were Grade II 31 & 11 Were Grade III. In this study, majority of tumours were grade II on cytology (66.1%). The next frequency was grade I (19.6%) followed by grade III (14.3%). Conclusion: Cytological grading of breast carcinoma can be done by Robinsons grading with quite relevance with histological grading and provide relevant information about invasive ductal carcinoma of breast which could be useful when selecting mode of therapy and to predict tumours behaviour. [ABSTRACT FROM AUTHOR]