Back to Search
Start Over
Single-center experience in the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma.
- Source :
-
Journal of Cancer Research & Clinical Oncology . Sep2023, Vol. 149 Issue 11, p8691-8697. 7p. - Publication Year :
- 2023
-
Abstract
- Purpose: Lymphoepithelioma-like hepatic carcinoma (LELC) is a rare malignant liver tumor and its preoperative diagnosis is challenging. The aim of this study was to optimize the diagnosis and treatment of LELC in a single large center. Methods: We conducted this retrospective analysis of 16 patients diagnosed with LELC in the First Affiliated Hospital of Zhejiang University between 2010 and 2022. Thirty-two cases of cholangiocarcinoma (ICC) and 48 cases of hepatocellular carcinoma (HCC) served as controls. Results: Most of the 16 patients with LELC included in this study had no specific symptoms. Histologically, 9 patients had lymphoepithelioma-like hepatocellular carcinoma (LEL-HCC), 5 had lymphoepithelioma-like cholangiocarcinoma (LEL-ICC) and 2 had LEL-HCC-ICC. LEL-HCC was usually accompanied by hepatitis B virus infection, while LEL-ICC was often accompanied by Epstein Barr virus (EBV) infection. During the follow-up period, no complication and deaths were observed and only one patient experienced recurrence. These results were obviously better than those in patients with HCC and ICC. Conclusion: LELC is a rare malignant hepatic tumor. There are no specific symptoms or imaging modalities for accurate preoperative diagnosis of LELC. The diagnosis can be confirmed by pathology; however, the prognosis of LELC after resection is promising. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEPATITIS B
*CARCINOMA
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 01715216
- Volume :
- 149
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Cancer Research & Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 167361888
- Full Text :
- https://doi.org/10.1007/s00432-023-04808-w