An Efficient Route towards Quinazolinone Derivatives via I2 /DMSO-Promoted Oxidative Decarboxylation of α-Amino Acids and Subsequent Oxidative Annulation Reaction.

Keywords: iodine; quinazolinones; amino acids; decarboxylation; dimethyl sulfoxide; oxidation EN iodine quinazolinones amino acids decarboxylation dimethyl sulfoxide oxidation 2561 2569 9 07/31/23 20230817 NES 230817 Graph Heteroarenes have remained as the center of attraction in the pharmaceutical industries over the decades. As a part of our continuing interest in the synthesis of novel heterocyclic compounds [41] and iodine-catalyzed method development, [43] we envisioned that quinazolinone derivatives may be prepared by using readily available 2-aminobenzamide derivatives and commercially inexpensive amino acids as coupling partners under iodine-catalyzed conditions. First of all, the amino acid phenylglycine was subjected to the optimum reaction conditions without having the 2-aminobenzamide derivative in the reaction mixture. A large number of quinazolinone derivatives and other related heterocyclic compounds were prepared via oxidative decarboxylation of the amino acids followed by an annulation reaction. [Extracted from the article]