Diiodine–Triethylsilane System: Formation of N -Alkylsulfonamides from Aldehydes or Ketones and Sulfonamides.

Then, an I N i -sulfonyl imine is formed from the aldehyde and the sulfonamide under catalysis by Et SB 3 sb SiH (Scheme 8b). [29] In the transformation, the sulfonamidation of the aldehyde or ketone is realized by using an I SB 2 sb -hydrosilane system at room temperature with EtOAc as the solvent. Keywords: sulfonamides; reductive amination; iodine; triethylsilane; green solvent EN sulfonamides reductive amination iodine triethylsilane green solvent 1634 1638 5 07/31/23 20230815 NES 230815 Graph I N i -Alkylsulfonamides are a class of useful amine compounds due to their extensive range of pharmaceutical and biological activities. [Extracted from the article]