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Vaccine-Elicited Memory Cytotoxic T Lymphocytes Contribute to Mamu-A 01-Associated Control of Simian/Human Immunodeficiency Virus 89.6P Replication in Rhesus Monkeys.
- Source :
-
Journal of Virology . Apr2005, Vol. 79 Issue 8, p4580-4588. 9p. 15 Graphs. - Publication Year :
- 2005
-
Abstract
- The expression of particular major histocompatibility complex (MHC) class I alleles can influence the rate of disease progression following lentiviral infections. This effect is a presumed consequence of potent cytotoxic T-lymphocyte (CTL) responses that are restricted by these MHC class I molecules. The present studies have examined the impact of the MHC class I allele Mamu-A*01 on simian/human immunodeficiency virus 89.6P (SHIV-89.6P) infection in unvaccinated and vaccinated rhesus monkeys by exploring the contribution of dominant-epitope specific CTL in this setting. Expression of Mamu-A*01 in immunologically naive monkeys was not associated with improved control of viral replication, CD4+ T-lymphocyte loss, or survival. In contrast, Mamu-A*01+ monkeys that had received heterologous prime/boost immunizations prior to challenge maintained higher CD4+ T-lymphocyte levels and better control of SHIV-89.6P replication than Mamu-A*01- monkeys. This protection was associated with the evolution of high-frequency anamnestic CTL responses specific for a dominant Mamu-A*01-restricted Gag epitope following infection. These data indicate that specific MHC class I alleles can confer protection in the setting of a pathogenic SHIV infection by their ability to elicit memory CTL following vaccination. [ABSTRACT FROM AUTHOR]
- Subjects :
- *T cells
*HIV
*SIMIAN viruses
*RHESUS monkeys
*VIRAL replication
*VACCINATION
Subjects
Details
- Language :
- English
- ISSN :
- 0022538X
- Volume :
- 79
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 16785946
- Full Text :
- https://doi.org/10.1128/JVI.79.8.4580-4588.2005