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Catalytic, asymmetric aza-Baylis–Hillman reaction of N-sulfonated imines with 2-cyclohexen-1-one and 2-cyclopenten-1-one in the presence of a chiral phosphine Lewis base
- Source :
-
Tetrahedron: Asymmetry . Apr2005, Vol. 16 Issue 7, p1385-1391. 7p. - Publication Year :
- 2005
-
Abstract
- Abstract: In the aza-Baylis–Hillman reaction of N-sulfonated imines with 2-cyclohexen-1-one or 2-cyclopenten-1-one, we found that by using (R)-2′-dimethylphosphanyl-[1,1′]binaphthalenyl-2-ol LB1 as a chiral phosphine Lewis base, the corresponding Baylis–Hillman adducts 2 or 3 can be obtained in good yields and moderate enantiomeric excess. The structure of this chiral phosphine Lewis base on chiral induction in this reaction has also been discussed. [Copyright &y& Elsevier]
- Subjects :
- *IMINES
*SULFONATES
*PHOSPHINE
*ORGANONITROGEN compounds
Subjects
Details
- Language :
- English
- ISSN :
- 09574166
- Volume :
- 16
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Tetrahedron: Asymmetry
- Publication Type :
- Academic Journal
- Accession number :
- 16836608
- Full Text :
- https://doi.org/10.1016/j.tetasy.2005.02.018