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Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1
- Source :
-
Biochemical & Biophysical Research Communications . May2005, Vol. 330 Issue 2, p461-466. 6p. - Publication Year :
- 2005
-
Abstract
- Abstract: It is generally thought that histone deacetylases (HDACs) play important roles in the transcriptional regulation of genes. However, little information is available concerning the specific functions of individual HDACs in disease states. In this study, two transgenic mice lines were established which harbored the human HDAC1 gene. Overexpressed HDAC1 was detected in the nuclei of transgenic liver cells, and HDAC1 enzymatic activity was significantly higher in the transgenic mice than in control littermates. The HDAC1 transgenic mice exhibited a high incidence of hepatic steatosis and nuclear pleomorphism. Molecular studies showed that HDAC1 may contribute to nuclear pleomorphism through the p53/p21 signaling pathway. [Copyright &y& Elsevier]
- Subjects :
- *TRANSGENIC mice
*CELL nuclei
*BILIARY tract
*GENES
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 330
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 16837627
- Full Text :
- https://doi.org/10.1016/j.bbrc.2005.02.179