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Pubertal stage and hypoglycaemia counterregulation in type 1 diabetes.
- Source :
-
Archives of Disease in Childhood . Feb2005, Vol. 90 Issue 2, p190-194. 5p. - Publication Year :
- 2005
-
Abstract
- Aims: To compare physiological and autonomic responses to acute hypoglycaemia in diabetic children in pre-, mid-, and post-pubertal stages of development. Methods: Twenty seven children (8 pre-pubertal, 7 mid-pubertal, 12 post-pubertal) with type 1 diabetes were studied. Hypoglycaemia was induced by insulin infusion until an autonomic reaction (R) was identified. Counterregulatory hormone levels were measured at baseline, R, R+1 5, and R+30 minutes. Haemodynamic changes and sweat production were measured. Results: The mean blood glucose level at R was lower in pre-pubertal than mid-pubertal children (2.0 v 2.5 mmol/l), and was positively correlated with HbA1c. Glucagon and noradrenaline responses to hypoglycaemia were minimal in all children. A brisk increase in pancreatic polypeptide (PP) concentration only occurred in post-pubertal children. Only two children showed a sweating response to hypoglycaemia. Conclusions: The blood glucose level at which sympatho-adrenal responses to hypoglycaemia were activated was associated with glycaemic control, and varied with pubertal stage. As in adults, the glucagon response to hypoglycaemia was deficient within a few years of developing diabetes. However, sweating and secretion of PP in response to hypoglycaemia did not occur until after puberty, indicating some qualitative differences from adults. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00039888
- Volume :
- 90
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Archives of Disease in Childhood
- Publication Type :
- Academic Journal
- Accession number :
- 16911396
- Full Text :
- https://doi.org/10.1136/adc.2004.052035