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Tumor Necrosis Factor-α G-308A Polymorphism and Sporadic IgA Nephropathy: A Meta-Analysis Using a Genetic Model-Free Approach.

Authors :
Tziastoudi, Maria
Chronopoulou, Ioanna
Pissas, Georgios
Cholevas, Christos
Eleftheriadis, Theodoros
Stefanidis, Ioannis
Source :
Genes. Jul2023, Vol. 14 Issue 7, p1488. 15p.
Publication Year :
2023

Abstract

Tumor necrosis factor-α (TNF-α) is a potent pro-inflammatory cytokine, involved in the pathogenesis and progression of immunoglobulin A nephropathy (IgAN). A bi-allelic polymorphism in the promoter region, at position -308 (G/A) of the TNF-α gene (rs1800629) is associated with an increased TNF-a production. However, several previous association studies of TNF-α G-308A polymorphism and IgAN rendered contradictory findings. The objective of the present study is to shed light on these inconclusive results and clarify the role of TNF-α and any possible contribution of this factor in the development and progression of sporadic IgAN. Therefore, a meta-analysis of all available genetic association studies relating the TNF-α G-308A polymorphism to the risk for development and/or progression of IgAN was conducted. Seven studies were included in the meta-analysis. Three of them included populations of European descent (Caucasians) and four involved Asians. The generalized odds ratio (ORG) was used to estimate the risk for the development and/or progression of the disease. Overall, the meta-analysis did not detect any significant association between the G-308A variant and both the risk of developing IgAN and the risk for progression of IgAN. In conclusion, these results suggest that TNF-α does not constitute a key component in the genetic architecture of sporadic IgAN. However, further evidence deciphering the influence of TNF-α on IgAN is still needed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734425
Volume :
14
Issue :
7
Database :
Academic Search Index
Journal :
Genes
Publication Type :
Academic Journal
Accession number :
169326041
Full Text :
https://doi.org/10.3390/genes14071488