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Potent inhibition of chitin synthase by an azasugar—investigation of synergistic effect with UDP.
- Source :
-
Journal of Enzyme Inhibition & Medicinal Chemistry . Apr2005, Vol. 20 Issue 2, p123-127. 5p. 1 Diagram, 3 Graphs. - Publication Year :
- 2005
-
Abstract
- We identified 6-deoxy-homoDMDP as a potent inhibitor of chitin synthase (Ki=38?µM), displaying an uncompetitive inhibition pattern. Dual inhibition was also performed with the enzymatic reaction product uridine 5'-diphosphate in order to evaluate the concurrent effect of both inhibitors. An interaction coefficient a of 0.9 was found, revealing synergistic inhibition. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHITIN
*GLYCOSYLTRANSFERASES
*ENZYMES
*ENZYME inhibitors
*URIDINE
Subjects
Details
- Language :
- English
- ISSN :
- 14756366
- Volume :
- 20
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Enzyme Inhibition & Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 16970549
- Full Text :
- https://doi.org/10.1080/14756360400014622