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Amyloid peptide hydrogels via formation of coordination polymers with Ag+ by its core peptide equipped with a C-cysteine.
- Source :
-
Chemical Communications . 8/14/2023, Vol. 59 Issue 63, p9599-9602. 4p. - Publication Year :
- 2023
-
Abstract
- We report that the core sequence of amyloid β (Aβ) peptide, KLVFF, when equipped with a C-terminal cysteine residue, exhibited an extremely low minimum hydrogelation concentration of 0.05 wt% in the presence of Ag+ in pH 5 buffer, with this concentration 2 orders of magnitude lower than that of the pentapeptide itself. The CD signal of the Ag+- L -KLVFFC hydrogel was observed to be sensitive to the early-stage aggregation of amyloid β peptide. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PEPTIDES
*C-terminal residues
*AMYLOID
*AMYLOID beta-protein
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 59
- Issue :
- 63
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 169750163
- Full Text :
- https://doi.org/10.1039/d3cc02076b