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Inducible nonhuman primate models of retinal degeneration for testing end-stage therapies.
- Source :
-
Science Advances . 8/4/2023, Vol. 9 Issue 31, p1-18. 18p. - Publication Year :
- 2023
-
Abstract
- The article discusses the challenge of testing retinal degeneration therapies due to anatomical differences between human and animal retinas. It presents three inducible cynomolgus macaque models of retinal degeneration such as optogenetics-based ablation, CRISPR-Cas9-induced rod-cone dystrophy, and an acute model using a polymer patch for photoreceptor separation.
- Subjects :
- *PHOTORECEPTORS
*RETINAL degeneration
*NEUROTROPHINS
*PRIMATES
Subjects
Details
- Language :
- English
- ISSN :
- 23752548
- Volume :
- 9
- Issue :
- 31
- Database :
- Academic Search Index
- Journal :
- Science Advances
- Publication Type :
- Academic Journal
- Accession number :
- 169798802
- Full Text :
- https://doi.org/10.1126/sciadv.adg8163