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Emodin‐Based Nanoarchitectonics with Giant Two‐Photon Absorption for Enhanced Photodynamic Therapy.
- Source :
-
Angewandte Chemie International Edition . 8/14/2023, Vol. 62 Issue 33, p1-5. 5p. - Publication Year :
- 2023
-
Abstract
- Two‐photon‐excited photodynamic therapy (TPE‐PDT) has significant advantages over conventional photodynamic therapy (PDT). However, obtaining easily accessible TPE photosensitizers (PSs) with high efficiency remains a challenge. Herein, we demonstrate that emodin (Emo), a natural anthraquinone (NA) derivative, is a promising TPE PS with a large two‐photon absorption cross‐section (TPAC: 380.9 GM) and high singlet oxygen (1O2) quantum yield (31.9 %). When co‐assembled with human serum albumin (HSA), the formed Emo/HSA nanoparticles (E/H NPs) possess a giant TPAC (4.02×107 GM) and desirable 1O2 generation capability, thus showing outstanding TPE‐PDT properties against cancer cells. In vivo experiments reveal that E/H NPs exhibit improved retention time in tumors and can ablate tumors at an ultra‐low dosage (0.2 mg/kg) under an 800 nm femtosecond pulsed laser irradiation. This work is beneficial for the use of natural extracts NAs for high‐efficiency TPE‐PDT. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 62
- Issue :
- 33
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 169828053
- Full Text :
- https://doi.org/10.1002/anie.202308019