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Self-powered dual-mode sensing strategy based on graphdiyne and DNA nanoring for sensitive detection of tumor biomarker.
- Source :
-
Biosensors & Bioelectronics . Oct2023, Vol. 237, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- MicroRNA-21 (miRNA-21) is currently the only known oncogenic miRNA that is upregulated in almost all malignant tumors and exhibits a broad spectrum of tumor recognition characteristics. It holds significant value in the early diagnosis, malignant degree assessment, and prognostic evaluation of tumors. In this study, a novel dual-mode self-powered sensing platform is developed using Au nanoparticles/graphdiyne as the electrode substrate and combined with DNA nanoring for highly sensitive and specific detection of miRNA-21. The DNA nanoring structure, which is easy to prepare and contains multiple recognition sites, induces significant electrochemical/colorimetric signal responses of the signaling molecule methylene blue. Under optimal conditions, the linear ranges of the electrochemical and colorimetric detection modes of this self-powered sensor are 0.1 fM-100 pM and 0.1 fM-10 nM, respectively, with the detection limits of 35.1 aM and 61.6 aM (S/N=3). This strategy provides a new reference for the sensitive detection of microRNA and has immense potential for application in the screening and detection of clinical nucleic acid diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DNA structure
*DNA
*GOLD nanoparticles
*METHYLENE blue
*BIOMARKERS
Subjects
Details
- Language :
- English
- ISSN :
- 09565663
- Volume :
- 237
- Database :
- Academic Search Index
- Journal :
- Biosensors & Bioelectronics
- Publication Type :
- Academic Journal
- Accession number :
- 169832326
- Full Text :
- https://doi.org/10.1016/j.bios.2023.115557