Keratoderma of palms and soles is an umbrella for the first manifestation of different skin diseases.

Backgound Keratoderma is a manifestation of different skin diseases whether inherited or acquired, systemic or cutaneous diseases, and is demonstrated as the thickening of the epidermis of palms and soles singly or in combination. Objective To record all cases of keratoderma those are seen in daily clinical practice over a specified period. Methods This is a case series descriptive study where all patients with keratoderma of palms and or soles were recorded during years between 2014-2022years. Full history and clinical examination were carried out aiming to establish the right clinical diagnosis and all demographic features were recorded. Biopsies for histopathological assessment were carried out in suspected cases and a scrape for fungus was done in patients with tinea as a confirmatory test. Results Forty-two patients with keratoderma were seen during this specified period, their ages ranged from 6 months-30years with a median of 6 years, with 32 (94%) males and 2 (5.88%) females. Regarding the diagnosis of keratoderma, 13(30.95%) with congenital, 11 (26%) with pityriasis rubra pilaris, 7 (16.66%) with lichen planus, 6 (14.7%) with dermatophytes and 5 (11.9%) with psoriasis. Conclusion Kertatoderma is a disease of male patients which has different etiological factors commonly congenital, followed by pityriasis rubra pilaris, then lichen planus, dermatophytes, and Psoriasis. Keratoderma could be the only manifestation of these diseases where the diagnosis could be very difficult, especially in the acquired variants. [ABSTRACT FROM AUTHOR]