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Curative Polyendocrine Therapy in a 21-year-Old Patient with Endometrial Carcinoma: Case Report and Review of the Literature.
- Source :
-
Oncology Research & Treatment . 2023, Vol. 46 Issue 7/8, p330-335. 6p. - Publication Year :
- 2023
-
Abstract
- Introduction: As the numbers of young patients diagnosed with early-stage endometrial carcinoma continue to rise, the question regarding fertility-preserving therapeutic options will increasingly gain significance in the future. Case Presentation: Here, we present the case of a 21-year-old patient diagnosed with symptomatic atypical endometrial hyperplasia. After 4 months of treatment with medroxyprogesterone acetate, a follow-up dilatation and curettage revealed early-stage, well-differentiated endometrioid endometrial carcinoma. Despite national guidelines recommending hysterectomy, the nulliparous patient expressed a desire to preserve her fertility. Subsequently, she underwent polyendocrine therapy with letrozole, everolimus, metformin, and Zoladex. Forty-three months after diagnosis, the patient successfully gave birth to a healthy child, and there have been no indications of recurrence thus far. Discussion: This case suggests that triple endocrine therapy may be an option for selected patients with early endometrial cancer and a desire for fertility-sparing therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22965270
- Volume :
- 46
- Issue :
- 7/8
- Database :
- Academic Search Index
- Journal :
- Oncology Research & Treatment
- Publication Type :
- Academic Journal
- Accession number :
- 169892800
- Full Text :
- https://doi.org/10.1159/000531661