2型糖尿病患者冠状动脉钙化与骨代谢指标的相关性 研究.

Objective To investigate the correlation between coronary arterial calcification (CAC) and osteoporosis in patients with type 2 diabetes. Methods 200 patients with type 2 diabetes mellitus were divided into coronary artery calcification group and control group according to the coronary artery calcification score. General data were recorded, and detected blood glucose, blood lipids, calcium, phosphorus, ALP, N-MID, B-CTX and other biochemical indices. Meanwhile, bone mineral density (BMD) and Coronary artery enhanced CT, to explore whether there is correlation between BMD, bone metabolism indexes and CAC and other indexes, on this basis, correlation analysis of related indexes in patients with coronary artery calcification group was further conducted. According to the result of enhanced coronary CT, the patients were divided into coronary stenosis group and non-coronary stenosis group to further explore the relationship between coronary stenosis and osteoporosis in type 2 diabetes patients. Results Age, ALP, waist circumference, BMI and fasting blood glucose (FBG) in the coronary artery calcification group were higher than those in the control group, and there were statistical differences (P < 0.05), but no statistically significant differences in bone mineral density and bone metabolism indexes between the two groups (P > 0.05) . Correlation analysis; P, 25(OH) D + B-CTX, PTH were negatively associated with lumbar spine and hip BMD (P < 0.05) . Previous history of coronary heart disease were positively correlated with lumbar BMD P < 0.05 ) and menopause years were negatively associated lumbar BMD (P < 0.05), while age, menopause years, systolic blood pressure, HDL-C and HOMA-IS were negatively associated with hip BMD (P < 0.05) . Logistic regression analysis of CAC and each index: Coronary artery calcification was correlated with coronary artery stenosis, history of coronary heart disease and carotid atherosclerosis (P < 0.05) . Logistic regression analysis of coronary artery stenosis and each index: There was significant correlation between coronary artery stenosis and coronary artery calcification and history of coronary heart disease (P<0.05). Conclusion This study confirmed that coronary artery stenosis is correlated with lumbar BMD, coronary artery calcification is significantly correlated with coronary artery stenosis; Coronary artery stenosis, previous history of coronary heart disease and carotid atherosclerosis were independent risk factors for coronary artery calcification and CAC was independent risk factors for coronary heart disease. Controlling blood glucose and osteoporosis in patients with type 2 diabetes may 20 reduce the risk of coronary heart disease. [ABSTRACT FROM AUTHOR]