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New Sesquiterpene Lactone via Fungal Transformation of Rhizopus oryzae KX685359: Antimicrobial In-Vitro and In-Silico Study.
- Source :
-
Catalysis Letters . Sep2023, Vol. 153 Issue 9, p2624-2632. 9p. - Publication Year :
- 2023
-
Abstract
- There is an urgent need for new chemical structures to develop drugs as a result of the increasing number of viruses and pathogenic bacteria that have the ability to resist established treatments. Phytochemical screening on Pulicaria species have yielded a lot of compounds specially terpenoids, importantly though, some compounds have been found to have a potent bioactivity. Pulicaria undulata plants considered as a productive source for the effective biologically secondary metabolites. Herein, 2α-Hydroxyalantolactone (1), a major secondary metabolite, was enzymatically transformed by Rhizopus oryzae KX685359 fungal isolate. The fungal transformation affords a new transformed metabolite2-(alantolactonyloxy) propanoic acid (2) and know alantolactone-2α-acetate (3). Antimicrobial assessment of the substrate and transformed compounds disclosed the moderate antimicrobial activity of compound (3) against Gram-negative E. coli, Gram-positive L. cereus and the unicellular yeast C. albicans. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1011372X
- Volume :
- 153
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Catalysis Letters
- Publication Type :
- Academic Journal
- Accession number :
- 169911284
- Full Text :
- https://doi.org/10.1007/s10562-022-04202-0