Back to Search
Start Over
Radiofrequency catheter ablation of premature ventricular complexes from right ventricular outflow tract improves left ventricular dilation and clinical status in patients without structural heart disease
- Source :
-
Journal of the American College of Cardiology (JACC) . Apr2005, Vol. 45 Issue 8, p1259-1265. 7p. - Publication Year :
- 2005
-
Abstract
- Objectives: The present study evaluated clinical benefits of radiofrequency catheter ablation (RFA) for premature ventricular complexes from right ventricular outflow tract (RVOT-PVC) in patients without structural heart disease. Background: It is unknown whether PVC causes left ventricular (LV) dilation, which is a well-recognized precursor of LV dysfunction and heart failure, and whether eliminating PVC by RFA produces clinical benefits in patients with RVOT-PVC. Methods: Frequency of PVC per total heart beats by 24-h Holter monitoring, left ventricular ejection fraction (LVEF), left ventricular end-diastolic internal dimension (LVDd), mitral regurgitation (MR) by echocardiogram, cardiothoracic ratio (CTR) by chest radiogram, and New York Heart Association (NYHA) functional class of 40 patients with RVOT-PVC without structural heart disease were evaluated before and 6 to 12 months after RFA. Results: Before RFA, a subgroup of patients with frequent (>20%) PVC demonstrated significantly enlarged LVDd and CTR, reduced LVEF, increased MR, and deteriorated NYHA functional class as compared to the subgroup with rare (<20%) PVC (54 ± 1 mm vs. 45 ± 1 mm, 52 ± 2% vs. 46 ± 1%, 66 ± 2% vs. 73 ± 2%, 1.2 ± 0.2 degree vs. 0.4 ± 0.1 degree, and 1.8 ± 0.2 vs. 1.3 ± 0.1, respectively; p < 0.05). Furthermore, ablating RVOT-PVC readily produced the improvement of all these abnormalities (47 ± 1 mm, 41 ± 1%, 72 ± 2%, 0.3 ± 0.1 degree, and 1.0 ± 0.0, respectively; p < 0.05 compared with before RFA). Conclusions: These findings suggest that frequent (>20%) RVOT-PVC may be a possible cause of LV dysfunction and/or heart failure, and RFA produces clinical benefits in these patients. [Copyright &y& Elsevier]
- Subjects :
- *HEART diseases
*CATHETER ablation
*LEFT heart ventricle
*HEART failure
Subjects
Details
- Language :
- English
- ISSN :
- 07351097
- Volume :
- 45
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of the American College of Cardiology (JACC)
- Publication Type :
- Academic Journal
- Accession number :
- 16992638
- Full Text :
- https://doi.org/10.1016/j.jacc.2004.12.073