Evaluation of factors associated with complications in liver abscesses.

Background: Liver abscess as an infectious space occupying lesion of the liver. Pyogenic and amoebic liver abscess is an infection that is emerging worldwide and that is associated with severe morbidity and considerable mortality. Aim: This study analyzes the predictive risk factors, clinical and socio-demographic features, complications and therapeutic management plan of liver abscesses patients. Methods: This prospective cross-sectional study was carried out in the department of surgery, in a tertiary care hospital, central India. A total of 135 cases, between 18-75 years of age, irrespective of sex, getting admitted in our department, during the period of study, diagnosed as liver abscess were included in the study. All patients were thoroughly examined and all relevant investigations were done. All complications and outcomes were observed. Result: Majority of the cases were 45-60 years age group. Most of the participant was male. The complications of liver abscess were mainly developed in alcoholic male than female. 58.5% of abscess present in right lobe of liver. Duration of alcohol consumption, BMI and socio-economic status was not significantly associated with the complication, most common clinical presentation were Fever, abdominal pain, tenderness and hepatomegaly. Raised total leukocyte count (>11000/comm), raised bilirubin (>2mg/dl) and increased liver enzymes were found in most of the cases. Most common complication was rupture of abscess in peritoneal and pleural cavity, peritonitis, Ascites and septic shock. Percutaneous aspiration combination with antibiotics has become the mainstay of treatment. Conclusion: The knowledge of predictive risk factors of liver abscess can allows early and appropriate treatment to avoid complications. Percutaneous drainage with appropriate antibiotics was associated with low rates of morbidity and mortality. [ABSTRACT FROM AUTHOR]