FORMULATION DEVELOPMENT, OPTIMIZATION, EVALUATION, AND STABILITY STUDIES OF ARIPIPRAZOLE NIOSOMES.

Niosomes were prepared using thin-film hydration and sonication techniques. For the film hydration method, surfactant, cholesterol, stearylamine (65.0:30.0:5.0 mM), and aripiprazole (2 mg) were dissolved in a mixture of chloroform:ethanol (3:1).The solvent was evaporated in vacuo on a field evaporator to form a thin film. Then hydrate the film with 10 ml of phosphate buffer (pH 7.4) using a stirrer. Surfactant, cholesterol, and stearylamine for sonication method (65.0:30.0:5.0 mM) and aripiprazole (2 mg) were placed in a beaker and 10 mL of phosphate buffer (pH 7.4) was added. I let it sit for 5 hours. A free dispersion (niosome) is synthesized 7 minutes before sonication is required.In the ether injection process, the solution containing the mixture of ether and surfactant slowly enters the aqueous solution (preheated to 60 °C) to evaporate the ether and synthesize the milky pest. Various parameters of the product such as percent encapsulation efficiency, vesicle size, polydispersity index and zeta potential were analyzed and selected as the best method for liposome production according to specification #1. [ABSTRACT FROM AUTHOR]