Artemeriosides A–F, the first examples of natural sesquiterpenoids substituted by a 6′-O-crontonyl β-glucopyranoside from Artemisia annua.

Artemeriosides A–F (1 – 6), six novel sesquiterpenoids containing a 6′- O -crontonyl β -glucopyranoside, were isolated from Artemisia annua L. Their structures were determined by spectral data including HRESIMS, IR, UV, 1D and 2D NMR, and ECD calculations. Compounds 1 – 6 represented the first examples of natural sesquiterpenoid substituted by 6′- O -crontonyl β -glucopyranoside. By antihepatoma assay, compounds 1 and 2 demonstrated inhibitory effect against both HepG2 and SK-Hep-1 cells with inhibitory ratios of 77.0%, 88.8%, and 86.8%, 83.9% at 200.0 μM, and compound 1 showed inhibitory activity against Huh7 cells with inhibitory ratio of 56.8%. [Display omitted] • Artemeriosides A–F (1–6) were isolated from A. annua. • Their structures contained 6′- O -crontonyl β -glucopyranoside. • Compounds 1–6 represented the first examples of natural sesquiterpenoid. • Compounds 1 and 2 showed activity against HepG2 and SK-Hep-1 cells at 200.0 μM. • Compound 1 showed inhibitory activity against Huh7 cells. [ABSTRACT FROM AUTHOR]