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Age and synovitis affect the results of the treatment of knee osteoarthritis with Microfragmented Autologous Fat Tissue.
- Source :
-
Knee Surgery, Sports Traumatology, Arthroscopy . Sep2023, Vol. 31 Issue 9, p3655-3664. 10p. 1 Color Photograph, 1 Black and White Photograph, 3 Charts, 3 Graphs. - Publication Year :
- 2023
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Abstract
- Purpose: This study aims to assess the effectiveness of Microfragmented Autologous Fat Tissue (MFAT) treatment for knee osteoarthritis and to investigate whether patients' pre-treatment clinical condition, such as synovitis, correlates with clinical outcomes, to identify potential predicting factors for the success or failure of the treatment. Methods: In this prospective Cohort Study Level II multicentric trial, consecutive patients with a diagnosis of early/mild osteoarthritis and failure of previous conservative measures were enrolled to undergo diagnostic arthroscopy and a single MFAT injection. Patients were assessed with repeated scoring systems at baseline, 6 months, and 12 months after surgery. The demographic features, the arthroscopic findings, the immunophenotype of injected tissue and the histologic examination of synovia of failed patients were analyzed. Results: Data from 91 patients showed a significant improvement in Lysholm, WOMAC scores at 1-year follow-up (p < 0.001). A significant decrease in VAS score was observed, while a significant improvement of measured flexion angle was registered at 1 year (p < 0.001). No major complications were reported. Age and synovitis were identified as significant factors influencing the clinical outcome (p < 0.05). Body mass index, previous or concomitant procedures, and specific cartilage defects had no influence. The mean number of injected adipose tissue-derived mesenchymal stem cells seem not to correlate with the clinical outcome. Conclusion: MFAT is effective in reducing pain when used with a single dose injection in early/mild OA of the knee, without major complications. Age over 60 and synovitis may be predictive for persistent pain at one year and should be considered before indications. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09422056
- Volume :
- 31
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Knee Surgery, Sports Traumatology, Arthroscopy
- Publication Type :
- Academic Journal
- Accession number :
- 170007633
- Full Text :
- https://doi.org/10.1007/s00167-022-07139-4