Back to Search
Start Over
Effect of Boswellic acids on T cell proliferation and activation.
- Source :
-
International Immunopharmacology . Sep2023, Vol. 122, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- • Boswellic acids have multiple beneficial pharmacological activities. • AKBA and β-BA have the ability to reduce proliferation and activation of T cells without cytotoxicity. • AKBA exhibits greater anti-proliferative effects and inhibits CD25 expression on T cells at a low concentration without affecting cell viability. • ABA has cytotoxic effects on T cells. Boswellic acids have been recognized as anti-inflammatory and immunomodulatory agents with potentials to control autoimmune and inflammatory diseases. However, their effects on T cell proliferation and activation are not fully elucidated. In this study, we investigated effects of individual compounds including β-Boswellic acids (β-BA), 11-keto-β-Boswellic acid (β-KBA), 3- O -acetyl β-Boswellic acids (β-ABA), and 3- O -acetyl-11-keto-β-Boswellic acid (β-AKBA) on human peripheral blood mononuclear cells (PBMCs) and their potential role in modulating immune responses. We showed that β-BA, KBA, and AKBA at a 0.025 µM concentration significantly reduced T cell proliferation without inducing cytotoxicity, however, ABA showed cytotoxic effects at this concentration. β-BA and KBA showed significantly reduced T cell proliferation at 0.05 µM concentration without cytotoxic effects. Interestingly, we found that AKBA at 0.025 µM concentration significantly reduced CD25 expression on both CD4+ and CD8+ T cells without cytotoxic effects. Additionally, β-BA reduced CD25 expression on both CD4+ and CD8+ T cells at 0.05 µM concentration with no cytotoxicity. In this study, we determined the optimum concentration of each of these compounds that have the potential to reduce T cell activation without cytotoxic effects. Our findings show that both β-BA and AKBA have the ability to inhibit T cell proliferation and activation without inducing cytotoxicity. Further investigations are required to fully understand the mechanisms underlying these effects and the potential therapeutic benefits of these compounds in different autoimmune and inflammatory settings. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15675769
- Volume :
- 122
- Database :
- Academic Search Index
- Journal :
- International Immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 170044607
- Full Text :
- https://doi.org/10.1016/j.intimp.2023.110668