熔体静电纺丝直写技术在组织工程中的应用.

BACKGROUND: With computer-aided design, melt electrowriting technology can precisely construct 3D tissue engineering scaffolds with specific morphology, which has attracted increasing attention in tissue engineering. OBJECTIVE: To elaborate on the progress of melt electrowriting technology in tissue engineering in recent years. METHODS: PubMed and CNKI were used to retrieve articles about applications of melt electrowriting technology in tissue engineering. The search time was from March 2008 to February 2023. The search terms were “melt electrowriting, melt electrospinning, electrospinning, tissue engineering, scaffold, regeneration” in English and “melt electrowriting, electrospinning, tissue engineering” in Chinese. A preliminary screening of articles was performed by reading the titles and abstracts. Finally, 69 articles were included for review. RESULTS AND CONCLUSION: (1) Melt electrowriting technology can achieve precise layer-by-layer deposition of fibers compared to traditional electrospinning technology, which better simulates the complex structure of natural tissues. Compared to other 3D printing technologies, smaller-diameter fibers can be prepared by melt electrowriting technology, resulting in highly ordered porous structures. (2) By combining with other scaffold preparation techniques or materials, such as fused deposition modeling, solution electrospinning technology, and hydrogel, melt electrowriting technology shows great potential in preparing complex tissue engineering scaffolds, which provides certain possibilities for achieving complex tissue regeneration. (3) The regeneration of complex tissues often involves blood vessels, nerves, and soft and hard tissues at the same time. The regeneration of blood vessels and nerves is of great significance to realize the physiological reconstruction of tissues. However, soft and hard tissues have certain difficulties to realize the coordinated regeneration of both due to their different biological and mechanical properties. Melt electrowriting technology has certain advantages in the field of bionic scaffolds due to its good biocompatibility, the ability to prepare multi-scale scaffolds and high porosity. [ABSTRACT FROM AUTHOR]