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Effects of platelet-rich fibrin and dexamethasone on nerve regeneration after acute facial-nerve injury.
- Source :
-
Acta Oto-Laryngologica . Jul2023, Vol. 143 Issue 7, p623-629. 7p. - Publication Year :
- 2023
-
Abstract
- Acute facial-nerve injury. To investigate the effects of platelet-rich fibrin (PRF) and dexamethasone on nerve regeneration. Thirty-six rats were randomly divided into six groups. Facial-nerve injury was created using a full-thickness incision in all groups except Group E. Next, primary anastomosis, PRF application, topical dexamethasone application, primary anastomosis with topical PRF and dexamethasone application, and no facial-nerve repair were performed in Groups A, B, C, D, and F, respectively. Clinical, functional, and structural improvements were evaluated at eight weeks. The mean eye-closure movement score in Group B was significantly higher than that in Group F (p <.001). The mean whisker-movement score in Group B was significantly higher than that in Group F (p =.001). The mean amplitude of whisker movement in Group F was significantly lower than those in Groups A, B, C, and E, and the mean amplitude in Group D was significantly lower than that in Group E (p <.001). Furthermore, an improvement in nerve ultrastructure was observed in Group B. PRF application has a positive effect on nerve recovery after anastomosis. Contribute to the literature to improve nerve regeneration. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EXPERIMENTAL design
*KRUSKAL-Wallis Test
*STATISTICS
*DEXAMETHASONE
*CONVALESCENCE
*ANIMAL experimentation
*FISHER exact test
*RATS
*DESCRIPTIVE statistics
*CUTANEOUS therapeutics
*MOTION capture (Human mechanics)
*DATA analysis
*FACIAL nerve
*NERVOUS system regeneration
*PLATELET-rich fibrin
*ANIMALS
Subjects
Details
- Language :
- English
- ISSN :
- 00016489
- Volume :
- 143
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Acta Oto-Laryngologica
- Publication Type :
- Academic Journal
- Accession number :
- 170064860
- Full Text :
- https://doi.org/10.1080/00016489.2023.2233085