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Long-term effects of octreotide therapy on in-stent restenosis.
- Source :
-
Heart & Vessels . Jul2003, Vol. 18 Issue 3, p130-135. 6p. - Publication Year :
- 2003
-
Abstract
- The purpose of this study was to assess the long-term effects of octreotide therapy on in-stent restenosis at 6-month follow-up coronary angiography and the clinical events after stenting. A randomized, double-blind, placebo-controlled trial was conducted to assess the effects of octreotide on restenosis after stenting. The patients (n = 148) received either subcutaneous octreotide or placebo 1 h before the stenting procedure and then every 8 h for 3 weeks. Percent diameter stenosis was interpreted before and after stenting, and on a 6-month follow-up coronary angiogram by quantitative coronary angiography. The mean percent diameter stenosis of the octreotide group was significantly lower than that of the placebo group on the 6-month follow-up coronary angiograms (18.8% ± 14.2% vs 35.0% ± 19.2%, respectively; P = 0.001). The restenosis rate of the octreotide group was statistically lower than that of the placebo group (11.8% vs 26.4%, respectively; P ≪ 0.05). With regard to major cardiovascular events, there was no significant difference between the octreotide and placebo groups. The administration of octreotide for treatment of in-stent restenosis results in a relatively low long-term angiographic restenosis rate and no significant acute effects on cardiovascular clinical events. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09108327
- Volume :
- 18
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Heart & Vessels
- Publication Type :
- Academic Journal
- Accession number :
- 17040124
- Full Text :
- https://doi.org/10.1007/s00380-003-0702-3