Cellular Signaling for Dental Physiological Functions.

When an inflammatory response is elicited in the dental pulp, internal tissue pressure increases, which mechanically stimulates dental pulp cells, including nerve terminals and odontoblasts [[7]]. The authors developed a model that mimicked the effect of increased tissue pressure on inflammatory responses in the dental pulp, and direct mechanical stimulation was applied to TG neurons. The [cAMP] SB i sb response from the odontoblasts approximating the stimulated TG neurons was measured using an odontoblast-neuron co-culture system. Saito et al. determined the role of the CGRP-CGRP receptor axis in axon reflex occurrence by measuring intracellular cyclic adenosine monophosphate (cAMP) ([cAMP] SB i sb ) levels via G SB s sb protein-coupled CGRP receptor activation in odontoblasts [[8]]. [Extracted from the article]