Back to Search Start Over

Enabling Efficient Design of Biological Formulations Through Advanced Characterization.

Authors :
Sonje, Jayesh
Thakral, Seema
Krueger, Susan
Suryanarayanan, Raj
Source :
Pharmaceutical Research. Jun2023, Vol. 40 Issue 6, p1459-1477. 19p.
Publication Year :
2023

Abstract

The present review summarizes the use of differential scanning calorimetry (DSC) and scattering techniques in the context of protein formulation design and characterization. The scattering techniques include wide angle X-ray diffractometry (XRD), small-angle neutron scattering (SANS) and small-angle X-ray scattering (SAXS). While DSC is valuable for understanding thermal behavior of the excipients, XRD provides critical information about physical state of solutes during freezing, annealing and in the final lyophile. However, as these techniques lack the sensitivity to detect biomolecule-related transitions, complementary characterization techniques such as small-angle scattering can provide valuable insights. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
07248741
Volume :
40
Issue :
6
Database :
Academic Search Index
Journal :
Pharmaceutical Research
Publication Type :
Academic Journal
Accession number :
170715383
Full Text :
https://doi.org/10.1007/s11095-023-03495-z