硫酸镁联合拉贝洛尔对重度子痫前期患者凝血功能、氧化应激 及血管内皮功能的影响.

Objective: To investigate the effects of magnesium sulfate combined with labetalol on coagulation function, oxidative stress and vascular endothelial function in patients with severe preeclampsia. Methods: 94 patients with severe preeclampsia who came to Chaohu Hospital affiliated to Anhui Medical University from January 2020 to September 2022 were selected. The patients were randomly divided into control group (magnesium sulfate treatment, 47 cases) and study group (magnesium sulfate combined with labetalol treatment, 47 cases) by random number table method. Before and after treatment, the changes of systolic blood pressure (SBP), diastolic blood pressure (DBP), 24 h urine protein volume (24hUP), coagulation function, oxidative stress and vascular endothelial function indexes were observed in two groups, and the drug safety in the two groups was observed. Results: After treatment, SBP, DBP and 24hUP in the study group were lower than those in the control group (P<0.05). After treatment, endothelin-1 (ET-1) in the study group was lower than that in the control group, while nitric oxide (NO) was higher than that in the control group (P<0.05). After treatment, malondialdehyde (MDA) in the study group was lower than that in the control group, and superoxide dismutase(SOD) in the study group was higher than that in the control group (P<0.05). After treatment, the fibrinogen (Fg) and D-dimer (D-D) in the study group were lower than those in the control group, and the prothrombin time (PT) and thrombin time (APTT) in the study group were higher than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions in the two groups (P>0.05). Conclusion: Labelolol combined with magnesium sulfate in the treatment of patients with severe preeclampsia can reduce 24hUP, effectively reduce blood pressure, improve coagulation function and vascular endothelial function, and alleviate oxidative stress damage. [ABSTRACT FROM AUTHOR]