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Dynamic contrast-enhanced MRI and sonography in patients receiving primary chemotherapy for breast cancer.
- Source :
-
European Radiology . Jun2005, Vol. 15 Issue 6, p1224-1233. 10p. - Publication Year :
- 2005
-
Abstract
- We compared dynamic contrast-enhanced MRI (DCE-MRI) and sonography (US) for monitoring tumour size in 21 patients with breast cancer undergoing primary chemotherapy (PCT) followed by surgery. The correlation between DCE-MRI and US measurements of tumour size, defined as the product of the two major diameters, was 0.555 (P=0.009), 0.782 (P<0.001), and 0.793 (P<0.001) at baseline, and after two and four cycles of PCT, respectively. The median tumour size was significantly larger when measured by DCE-MRI than by US at baseline (1472 vs 900 mm(2), P<0.001) and after two cycles of PCT (600 vs 400 mm(2), P=0.009). After PCT, the median tumour size measured by the two techniques was similar (256 vs 289 mm(2) for DCE-MRI and US, respectively, P=0.859). The correlation with the histopathological major tumour diameter was 0.824 (P<0.001) and 0.705 (P<0.001) for post-treatment DCE-MRI and US, respectively. Measurements of the final major tumour diameter by DCE-MRI tended to be more precise, including cases achieving a pathological complete response. Randomized trials are warranted to establish the clinical impact of the initial discrepancy in tumour size estimates between DCE-MRI and US, and the trend towards a better definition of the final tumour size provided by DCE-MRI in this clinical setting. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BREAST cancer surgery
*DRUG therapy
*ULTRASONIC imaging
*CANCER patients
*MEDICAL imaging systems
*ANTINEOPLASTIC agents
*BREAST tumors
*COMPARATIVE studies
*DOXORUBICIN
*MAGNETIC resonance imaging
*RESEARCH methodology
*MEDICAL cooperation
*NONPARAMETRIC statistics
*PACLITAXEL
*RESEARCH
*TUMOR classification
*EVALUATION research
*CONTRAST media
TUMOR surgery
Subjects
Details
- Language :
- English
- ISSN :
- 09387994
- Volume :
- 15
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- European Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 17090078
- Full Text :
- https://doi.org/10.1007/s00330-005-2656-6