Correspondence comprehensive characterization of a brainstem aggregoma (light and heavy chain deposition disease).

(B) mRNA expression of select immunoglobulin chain genes (detected at highest abundance in LC-MS/MS data) in a cohort of 153 pediatric CNS lesions. (A) Most abundant proteins detected by LC-MS/MS analysis of the LHCDD - number of proteins compared with the total spectrum count. Our patient sample is highlighted in red. (C) Ingenuity pathway analysis pathway analysis showed elevated immune pathways with a positive Z score, confirming the findings from LC-MS/MS. Keywords: aggregoma; genomic profiling; immunoglobulin kappa-chains; light and heavy chain deposition disease; mass spectrometry EN aggregoma genomic profiling immunoglobulin kappa-chains light and heavy chain deposition disease mass spectrometry 1 5 5 09/01/23 20230901 NES 230901 Monoclonal immunoglobulin (Ig) deposition diseases are classified as heavy chain deposition disease (HCDD); light chain deposition diseases (LCDD); and light and heavy chain deposition disease (LHCDD) - deposits of both light [kappa ( ) and lambda ( )], and heavy [alpha ( ), delta ( ), epsilon ( ), gamma ( ), and mu ( )] Ig chains. [Extracted from the article]