铁死亡在骨关节炎中的作用机制及其中医药干预研究进展.

BACKGROUND: Studies have found that chondrocyte ferroptosis can be used as an important pathogenesis to induce the occurrence and development of osteoarthritis. With the continuous development of Chinese medicine, some scholars have found that some traditional Chinese medicine monomers and traditional Chinese medicine compounds can inhibit chondrocyte ferroptosis through various mechanisms of action, and finally play a role in the treatment of osteoarthritis. OBJECTIVE: To explore the relationship between ferroptosis and osteoarthritis and the mechanism by which traditional Chinese medicine deals with ferroptosis in the treatment of osteoarthritis, in order to provide new ideas for the treatment and prevention of osteoarthritis. METHODS: With “osteoarthritis, ferroptosis, chondrocytes, lipid metabolism, traditional Chinese medicine, ROS, GPX 4” as the English and Chinese search terms, CNKI, PubMed, WanFang, and VIP databases were searched for relevant articles regarding the relationship between ferroptosis and osteoarthritis and its traditional Chinese medicine intervention until 2022. Then, a systematic analysis was conducted. RESULTS AND CONCLUSION: Intracellular iron overload will cause lipid peroxidation, resulting in the accumulation of reactive oxygen species and eventually the occurrence of ferroptosis, while excessive iron will accelerate the apoptosis of chondrocytes and affect chondrocyte homeostasis, thereby inducing the development of osteoarthritis. When amino acid metabolism is abnormal, an imbalance in glutamate and cystine exchange causes the accumulation of glutamate outside the cells, and high extracellular concentration of glutamate will cause the depletion of glutathione, indirectly inhibiting the function of ferroptosis-related factors, and contributing to ferroptosis. When cellular lipid metabolism is abnormal, unsaturated fatty acids, an important component of the cell membrane, lose their diallyl hydrogen atoms, leading to the destruction of cells to induce ferroptosis, while lipid metabolism is closely involved in the progression of osteoarthritis. Traditional Chinese medicine can play a role in the prevention and treatment of osteoarthritis by inducing the occurrence of ferroptosis. The research on iron death is still immature, and further research on its action mechanism is expected to open up new ways for the clinical treatment of osteoarthritis. [ABSTRACT FROM AUTHOR]