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A stable core-shell metal-organic framework@covalent organic framework composite as solid-phase extraction adsorbent for selective enrichment and determination of flavonoids.
- Source :
-
Journal of Chromatography A . Sep2023, Vol. 1707, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- • A stable core-shell MOF@COF composite was synthesized and utilized as SPE adsorbent. • The covalent integration of hydrophobic COF shell successfully enhanced the hydrophobicity of MOF core. • The excellent extraction efficiency was attributed to the presence of multiple interactions. • A sensitive method for the quantification of flavonoids in grape juice and honey samples was developed. Hydrophobization and stability is crucial for the practical application of most metal-organic frameworks (MOFs) in extraction technique. In this study, a stable core-shell MOF@COF composite (NH 2 -MIL-101(Fe)@TAPB-FPBA-COF) was successfully prepared by Schiff base reaction and applied to solid-phase extraction (SPE) of hydrophobic flavonoids. Notably, the TAPB-FPBA-COF shell acts as a hydrophobic "shield", which not only improves the hydrophobicity and stability of hydrophilic NH 2 -MIL-101(Fe), but also makes the extraction efficiency of flavonoids from MOF@COF composite significantly higher than that of pure NH 2 -MIL-101(Fe) and TAPB-FPBA-COF. In addition, a sensitive analytical method with excellent linearities (0.1–500 ng mL−1, R2 ≥ 0.9967), low limits of detection (0.02–0.04 ng mL−1 for water; 0.04–0.07 ng mL−1 for grape juice; 0.06–0.08 ng mL−1 for honey), good repeatability (intra-day/inter-day precision are 1.86–5.37%/1.82–7.79%, respectively) and only 5 mg of adsorbent per cartridge was established by optimizing the SPE process combined with high performance liquid chromatography with ultraviolet-visible detector (HPLC-UV). Meanwhile, selectivity study and comparative experiments with the commercial C18 adsorbent showed that the MOF@COF adsorbent exhibited satisfactory extraction efficiency for flavonoids due to multiple interactions such as hydrogen bonding, hydrophobic, and π-π interactions. Finally, the good recoveries in grape juice (84.5–102.5%) and honey (87.5–104.6%) samples further validated the applicability of the proposed method in complex samples. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00219673
- Volume :
- 1707
- Database :
- Academic Search Index
- Journal :
- Journal of Chromatography A
- Publication Type :
- Academic Journal
- Accession number :
- 171368238
- Full Text :
- https://doi.org/10.1016/j.chroma.2023.464324