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Hantzsch‐like reaction of isoquinoline‐1‐acetonitrile in synthesis of 4H‐pyrido[2,1‐a]isoquinolines with antibacterial evaluation.
- Source :
-
Journal of Heterocyclic Chemistry . Sep2023, Vol. 60 Issue 9, p1565-1571. 7p. - Publication Year :
- 2023
-
Abstract
- The in vitro antibacterial activity of brand‐new fused pyrido[2,1‐a]isoquinoline compounds was investigated. The desired pyrido[2,1‐a]isoquinoline derivatives 5, 9, and 10 were obtained by heating 2‐(6,7‐dimethoxy‐3,4‐dihydroisoquinolin‐1‐yl)acetonitrile 1 with ethylacetate derivatives 2, 6, and 7 in refluxing acetonitrile, while piperidine was present as a catalytic quantity. Under the same conditions, compound 1 was refluxed with compounds 11a–f to give the corresponding compounds 12a–f. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ISOQUINOLINE
*ACETONITRILE
*PIPERIDINE
*ANTIBACTERIAL agents
Subjects
Details
- Language :
- English
- ISSN :
- 0022152X
- Volume :
- 60
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Heterocyclic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 171368993
- Full Text :
- https://doi.org/10.1002/jhet.4701