Synthesis and antibacterial evaluation of alkaloid-like phenylfuroacridones.

A number of new alkaloid-like phenylfuroacridones were synthesized by cyclization in polyphosphoric acid of 2-, 3 -, 4-(2-oxo-2-phenylethoxy)acridones, which, in turn, were obtained by O-alkylation of the corresponding 2-, 3-, 4-hydroxyacridones with phenacyl bromide. Biological studies showed that phenylfuroacridones exhibited a low antibacterial activity against the test strain Candida albicans. [ABSTRACT FROM AUTHOR]