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An overview of mouse models of hepatocellular carcinoma.
- Source :
-
Infectious Agents & Cancer . 9/5/2023, Vol. 18 Issue 1, p1-17. 17p. - Publication Year :
- 2023
-
Abstract
- Hepatocellular carcinoma (HCC) has become a severe burden on global health due to its high morbidity and mortality rates. However, effective treatments for HCC are limited. The lack of suitable preclinical models may contribute to a major failure of drug development for HCC. Here, we overview several well-established mouse models of HCC, including genetically engineered mice, chemically-induced models, implantation models, and humanized mice. Immunotherapy studies of HCC have been a hot topic. Therefore, we will introduce the application of mouse models of HCC in immunotherapy. This is followed by a discussion of some other models of HCC-related liver diseases, including non-alcoholic fatty liver disease (NAFLD), hepatitis B and C virus infection, and liver fibrosis and cirrhosis. Together these provide researchers with a current overview of the mouse models of HCC and assist in the application of appropriate models for their research. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17509378
- Volume :
- 18
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Infectious Agents & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 171387112
- Full Text :
- https://doi.org/10.1186/s13027-023-00524-9