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An effective HBT/indanone-based fluorescent probe for cysteine detection in cells.
- Source :
-
Dyes & Pigments . Nov2023, Vol. 219, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- The abnormality of Cys concentration in organism could lead to a series of diseases, so its effective detection is of great importance in disease diagnosis. Here we developed a novel ESIPT fluorescent probe HBT-IDAc based on the classic ESIPT fluorophore 2-(2′-hydroxyphenyl)benzothiazole (HBT) and indanone, which could selectively and sensitively detect Cys with a large Stokes shift up to 210 nm and the detection limit to 0.89 μM. In addition, the probe exhibited good anti-interference and low cytotoxicity, and has been successfully applied to monitor Cys in cells. • A novel ESIPT fluorescent probe for selective and sensitive detection of Cys was developed. • The probe has the large stokes shift (210 nm) and good LOD (0.89 μM) in aqueous environment. • The probe exhibits low cytotoxicity and has been applied for imaging Cys in cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01437208
- Volume :
- 219
- Database :
- Academic Search Index
- Journal :
- Dyes & Pigments
- Publication Type :
- Academic Journal
- Accession number :
- 171392850
- Full Text :
- https://doi.org/10.1016/j.dyepig.2023.111649