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Multitarget inhibitors/probes that target LRRK2 and AURORA A kinases noncovalently and covalently.
- Source :
-
Chemical Communications . 9/16/2023, Vol. 59 Issue 72, p10789-10792. 4p. - Publication Year :
- 2023
-
Abstract
- Herein, we report a salicylaldehyde-based, reversible covalent inhibitor (A2) that possesses moderate cellular activity against AURKA with a prolonged residence time and shows significant non-covalent inhibition towards LRRK2. Our results indicated that this multitarget kinase inhibitor may be used as the starting point for future development of more potent, selective and dual-targeting covalent kinase inhibitors against AURKA and LRRK2 for mitophagy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AURORA kinases
*DARDARIN
*KINASE inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 59
- Issue :
- 72
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 171807655
- Full Text :
- https://doi.org/10.1039/d3cc03530a