The stability of the gut, oral, and circulating microbiomes in living kidney donors: A 2 years prospective study.

With this 24-months stability, we believe that the gut, circulating (blood), and oral microbiomes of LKD may have limited impact to assess long-term risks of cardiovascular and kidney disease in LKD. Changes in the post-transplantation gut microbiome have been described in kidney transplant recipients (KTR), namely a decrease in overall microbial diversity and an increase in Enterobacteriaceae.[[1]] In addition, gut microbiome may influence tacrolimus dosage, and, in a bidirectional relation, the immunosuppressive therapy and the infection and rejection episodes may alter gut microbiome.[3] In the last decade, several alerts have been raised on the long-term risks of living kidney donors (LKD) regarding kidney and cardiovascular disease.[4] While considering these warnings, additional tools should be explored to help to assess these risks in LKD. [Extracted from the article]