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Synthesis of 2-Benzyl-3-(2-oxo-2-phenylethyl)isoindolin-1-one Derivatives in Water under Catalyst-Free Conditions.
- Source :
-
Synthesis . Oct2023, Vol. 55 Issue 19, p3172-3178. 7p. - Publication Year :
- 2023
-
Abstract
- Reaction conditions: o -formylbenzoic acid (1a) (0.2 mmol), benzylamine (2a) (0.2 mmol), acetophenone (3a) (0.6 mmol), H 2 O (1 mL), 70 °C. When the molar ratio of I o i -formylbenzoic acid/benzylamine/acetophenone was 1:1:3, the highest yield of 71% was obtained. Reaction conditions: o -formylbenzoic acid (1a) (0.2 mmol), benzylamine (2a) (0.2 mmol), acetophenone (3a) (0.6 mmol), H 2 O (1 mL), 12 h. Keywords: isoindolin-1-one; water; catalyst-free; three-component reaction; o -formylbenzoic acid EN isoindolin-1-one water catalyst-free three-component reaction o -formylbenzoic acid 3172 3178 7 09/11/23 20231004 NES 231004 Graph Nitrogen-containing heterocycles are an important class of compounds, and form the basic skeletons of many drugs, natural products, and functional materials. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 55
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 171833920
- Full Text :
- https://doi.org/10.1055/a-2103-4915