A Cd-based MOF as a fluorescent sensor for highly sensitive detection of anthrax biomarkers.

Here, we synthesized a novel three-dimensional cadmium-based MOF (Cd-DPNA). It has high selectivity and sensitivity to the biomarker (DPA) of Bacillus anthracis, which provides a new idea for the detection of DPA by MOF-based fluorescence sensing method. [Display omitted] • 3D Cd-DPNA was successfully synthesized and characterized. • The fluorescence intensity of Cd-DPNA is quenched by adding DPA. • The low detection limit of Cd-DPNA for DPA is 3.04 μM. • Cd-DPNA detects DPA with very high selectivity, excellent recyclability and rapid response. • In the actual sample detection, Cd-DPNA has high detection accuracy and has potential for practical application. Anthracnose caused by Bacillus anthracis is an acute infectious disease that has the greatest impact on grazing livestock and wild ungulates, and poses a serious threat to human health. Therefore, it is of great research significance and application value to develop a fluorescent sensor that can detect the markers of Bacillus anthracis. Based on this, a three-dimensional Cd-based MOF (Cd-DNPA) was synthesized by solvothermal method. It is worth noting that it exhibits high selectivity and high sensitivity to 2,6-pyridine dicarboxylic acid (DPA), the calculated Ksv is 2.3686 × 103 M−1, the detection limit (LOD) is as low as 3.04 μM. In addition, the sensor can be detected in actual samples, and the recovery value is 98% −103%, indicating that it has the potential for practical application. [ABSTRACT FROM AUTHOR]