Novel high yielding route for the synthesis of Melphalan dimer impurity G.

Melphalan dimer is an impurity from the synthesis of Melphalan (M216900) which is an antineoplastic agent. In this article, a new route for the synthesis of Melphalan dimer impurity G has been discussed. The new research provides the first high-yield, high-purity synthesis of this impurity. The impurity has been confirmed for purity using HPLC, and its structure has been identified using MS, ¹H and 13C NMR. [ABSTRACT FROM AUTHOR]