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An alternate synthesis of sporiolide B from (R)-glyceraldehyde.
- Source :
-
Synthetic Communications . 2023, Vol. 53 Issue 16, p1333-1338. 6p. 1 Diagram, 2 Graphs. - Publication Year :
- 2023
-
Abstract
- In this article, a novel synthetic route was described for the total synthesis of Sporiolide B from inexpensive and commercially available starting materials by a concise fourteen-step sequence in 6.50% overall yield. This convergent synthesis utilizes Grignard reaction, Asymmetric dihydroxylation, Yamaguchi macrolactonization and ring closing metathesis as the key steps. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GRIGNARD reagents
Subjects
Details
- Language :
- English
- ISSN :
- 00397911
- Volume :
- 53
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Synthetic Communications
- Publication Type :
- Academic Journal
- Accession number :
- 171935663
- Full Text :
- https://doi.org/10.1080/00397911.2023.2220443