PREDICTION OF POST-STROKE DEPRESSION WITH COMBINED BLOOD BIOMARKERS IL-6, TNF-α, AND FATTY ACID BINDING PROTEIN: A PROSPECTIVE STUDY.

Background: To investigate the expression levels of blood biomarkers interleukin-6 (IL-6), tumour necrosis factor (TNF-α), and intestinal fatty acid binding protein (iFABP) in patients with post-stroke depression (PSD), and their correlation with PSD occurrence. Methods: Clinical data of stroke patients admitted to the First People's Hospital of Wenling from December 2017 to December 2022 were retrospectively analyzed. Patients were classified into two groups based on their Hamilton Depression Rating Scale (HAMD) scores: PSD and non- PSD groups. The blood levels of IL-6, TNF-α, and iFABP were compared between the two groups, and their association with PSD occurrence was analyzed. Results: The PSD group had significantly higher levels of IL-6, TNF-α, and iFABP. The combined detection of these biomarkers demonstrated a greater predictive value for PSD occurrence compared to the individual detection of each biomarker. Conclusions: The study indicates that the levels of IL-6, TNF-α, and iFABP in the blood are significantly increased in patients with PSD. The combined detection of these biomarkers can effectively predict the occurrence of PSD, indicating high clinical value. Urod: Cilj je bio da se istraži ekspresija biomarkera u krvi interleukina-6 (IL-6), faktora tumorske nekroze (TNF-a) i proteina koji vezuje masne kiseline creva (iFABP) kod pacijenata sa depresijom nakon moždanog udara (PSD) i njihovim korelacija sa pojavom PSD-a. Metode: Retrospektivno su analizirani klinički podaci pacijenata sa moždanim udarom koji su primljeni u Prvu narodnu bolnicu Vbnling od decembra 2017. do decembra 2022. godine. Pacijenti su klasifikovani u dve grupe na osnovu rezultata Hamiltonove skale za procenu depresije (HAMD): PSD i ne-PSD grupe. Nivoi IL-6, TNF-a i iFABP u krvi su upoređeni između dve grupe i analizirana je njihova povezanost sa pojavom PSD. Rezultati: PSD grupa je imala značajno više nivoe IL-6, TNF- a i iFABP Kombinovana detekcija ovih biomarkera pokazala je veću prediktivnu vrednostza pojavu PSD-a u poređenju sa pojedinačnom detekcijom svakog biomarkera. Zaključak: Studija ukazuje da su nivoi IL-6, TNF-a i iFABP u krvi značajno povećani kod pacijenata sa PSD. Kombinovana detekcija ovih biomarkera može efikasno predvideti pojavu PSD-a, što ukazuje na visoku kliničku vrednost. [ABSTRACT FROM AUTHOR]