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Interaction of estradiol and vitamin D with low skeletal muscle mass among middle-aged and elderly women.
- Source :
-
BMC Women's Health . 9/15/2023, Vol. 23 Issue 1, p1-9. 9p. - Publication Year :
- 2023
-
Abstract
- Background: Since the connection between muscle atrophy and vitamin D and estradiol status ambiguous, this study was thus conducted to determine whether low skeletal muscle mass (SMM) in middle-aged and elderly women was affected by estradiol and vitamin D levels together. Methods: Baseline data from a sub-cohort of the China Northwest Natural Population Cohort: Ningxia Project (CNC-NX) were analyzed. Serum 25-hydroxyvitamin D (25(OH) D) and estradiol were measured by chemiluminescence immunoassay analyzer. Bivariate logistic regression and multiplicative interaction analyses were used to assess the impact of estradiol level and vitamin D status on low SMM, as well as the combined impact of estradiol and low vitamin D status on low SMM. Results: A total of 287 (9.49%) participants had low SMM, which had lower levels of estradiol and vitamin D concentration than normal SMM group. While, after adjusting the confounding variables, these correlations were maintained in estradiol Q1, Q2, Q3 and vitamin D Q1. Furthermore, the significant combined effect of the highest quartile of estradiol concentrations and non-vitamin D deficiency, and interactions between vitamin D Q1 and estradiol Q2, vitamin D Q1 and estradiol Q3, vitamin D Q2 and estradiol Q1, vitamin D Q3 and estradiol Q3 on low SMM were stably reflected (P for interaction < 0.05). Conclusions: Estradiol and vitamin D were interrelated with low SMM in middle-aged and elderly women. Combination of estradiol and vitamin D supplements should be encouraged for middle-aged and elderly women who are at risk of muscle atrophy or experiencing muscle atrophy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VITAMIN D
*OLDER women
*MIDDLE-aged women
*MUSCLE mass
*ESTRADIOL
Subjects
Details
- Language :
- English
- ISSN :
- 14726874
- Volume :
- 23
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Women's Health
- Publication Type :
- Academic Journal
- Accession number :
- 171992666
- Full Text :
- https://doi.org/10.1186/s12905-023-02646-z