Cu-hemin multilayer nanosheets with integration of peroxidase and photothermal properties for efficient synergistic sterilization.

Cu-hemin@IR780 nanocomposites were synthesized by a green method. Compared with Cu-hemin, the photothermal ability of Cu-hemin@IR780 under NIR is significantly improved, and the antibacterial activity is greatly enhanced under the synergistic effect with CDT. [Display omitted] • Cu-hemin@IR780 with multilayer nanosheets structure was successfully synthesized. • The nanosheets has the ability to catalyze the production of ·OH. • The nanosheets has excellent photothermal conversion performance. • The nanosheets integrates peroxidase and photothermal properties to achieve synergistic sterilization. The increasing drug resistance of bacteria due to the inappropriate use of various antibiotics has become an ongoing public health problem around the world. In this work, a novel Cu-hemin nanosheet with multilayer structure was synthesized by a simple green method. Integrating the peroxidase properties of hemin with the excellent photothermal conversion performance of IR780, the as-prepared Cu-hemin@IR780 can not only effectively catalyze hydrogen peroxide to produce reactive oxygen species (ROS), but also has a highly efficient and stable photothermal effect for sterilization. The antibacterial efficiency against MRSA can reach up to 98.96% by using chemodynamic therapy (CDT) and photothermal therapy (PTT) for synergistic sterilization. [ABSTRACT FROM AUTHOR]